Article Dans Une Revue Nature Reviews Drug Discovery Année : 2024

Targeting metabolic dysfunction of CD8 T cells and natural killer cells in cancer

Résumé

The importance of metabolic pathways in regulating immune responses is now well established, and a mapping of the bioenergetic metabolism of different immune cell types is under way. CD8 T cells and natural killer (NK) cells contribute to cancer immunosurveillance through their cytotoxic functions and secretion of cytokines and chemokines, complementing each other in target recognition mechanisms. Several immunotherapies leverage these cell types by either stimulating their activity or redirecting their specificity against tumour cells. However, the anticancer activity of CD8 T cells and NK cells is rapidly diminished in the tumour microenvironment, closely linked to a decline in their metabolic capacities. Various strategies have been developed to restore cancer immunosurveillance, including targeting bioenergetic metabolism or genetic engineering. This Review provides an overview of metabolic dysfunction in CD8 T cells and NK cells within the tumour microenvironment, highlighting current therapies aiming to overcome these issues.

Domaines

Immunologie
Fichier sous embargo
Fichier sous embargo
0 3 19
Année Mois Jours
Avant la publication
jeudi 12 juin 2025
Fichier sous embargo
jeudi 12 juin 2025
Connectez-vous pour demander l'accès au fichier

Dates et versions

hal-04879757 , version 1 (13-02-2025)

Identifiants

Citer

Sébastien Viel, Eric Vivier, Thierry Walzer, Antoine Marçais. Targeting metabolic dysfunction of CD8 T cells and natural killer cells in cancer. Nature Reviews Drug Discovery, 2024, ⟨10.1038/s41573-024-01098-w⟩. ⟨hal-04879757⟩
3 Consultations
0 Téléchargements

Altmetric

Partager

More