The prime objective of this doctoral work is to assist geographically neighboring industries to evolve towards becoming an eco-industrial park (EIP). Indeed, circular economy, which is regenerative by design as opposed to the prevailing extractive linear model, is gaining momentum as an answer for migrating towards a sustainable paradigm. Many literature studies were conducted to assess the feasibility of heating networks based on industrial heat recovery and similarly for material reuse and recycling aiming to propose technical options for better energy efficiency and resource use whether on the process scale or on a larger inter-sites level. However reacting conversion systems create new valorization opportunities for the energy or material streams, adjudicated as non-usable by conventional process integration techniques, through converting them into new recoverable products and thus reintroducing them back into the production cycle. In this perspective, two novel conceptual frameworks, for incorporating reacting thermodynamic conversion systems to the material and energy integration problems in both cooperative and non-cooperative schemes, were proposed in this doctoral dissertation. The application of the proposed methodological frameworks on a realistic industrial park demonstrated how to implement conversion processes in a territory that reinsert streams judged to be non-recoverable by conventional on-site and inter-site energy and material integration techniques ensuing substantial operating costs savings and enhancing the park's circular economy. The non-usable stream in the investigated park is woody biomass for which three conversion routes were challenged being the wood to hydrogen, methane production and cogeneration.